Understanding GLP-1 Medications and the Microbiome: Insights from Dr. Arun Dhir
In a recent episode of the Australian Weight Loss Surgery Podcast, Dr. Arun Dhir joined host Jacqui Lewis to discuss groundbreaking insights into obesity treatments, lifestyle factors, and the role of the gut microbiome. Their conversation highlighted how emerging medications like GLP-1 drugs are reshaping the landscape of obesity management and overall health.
What Are GLP-1 Medications?

GLP-1 (Glucagon-Like Peptide-1) medications have gained attention for their effectiveness in managing obesity and type 2 diabetes. These drugs work by mimicking the natural GLP-1 hormone, which regulates blood sugar levels, reduces appetite, and slows digestion—key factors in weight loss and metabolic health.
Dr. Arun explained that understanding these medications goes beyond their immediate benefits. “I was listening to The Oprah Show recently, where patient advocates shared their experiences with GLP-1s,” he noted. The combination of medical expertise and personal stories offers a clearer picture of how these treatments affect real people.
Additionally, Dr. Arun explores potential side effects such as gastroparesis and muscle loss, emphasising that these medications should be part of a holistic approach rather than a standalone solution.
The Role of the Gut Microbiome

During the podcast, Dr. Arun emphasised the link between the gut microbiome and overall well-being. “Our gut microbiome isn’t just about digestion,” he explained. “It plays a crucial role in skin health, immune function, and even mental well-being.”
Dr. Arun’s research has shown how gastric bypass surgery alters the gut microbiome, improving insulin sensitivity and reducing inflammation. He also discusses how the gut microbiome affects metabolism and plays a key role in long-term weight management.
Poor lifestyle choices, processed foods, and environmental toxins can create a “toxic” gut environment, contributing to various health issues. Dr. Arun urged listeners to consider holistic approaches to gut health, including:
Eating fibre-rich foods to nourish beneficial bacteria
Reducing processed food intake
Managing stress, which can directly impact gut balance
Lifestyle Factors in Obesity Management
Dr. Arun also addressed modern lifestyle habits that contribute to poor health outcomes. “We live in a world of remote controls and video games. We sit, eat mindlessly, and rarely engage in active play,” he remarked. This sedentary behaviour, combined with environmental factors like microplastics, poses long-term risks for metabolic and hormonal balance.
He emphasises the importance of strength training to prevent muscle loss during weight loss and discusses how factors such as stress, environmental toxins, and ultra-processed foods significantly impact our health.
Embracing Continuous Learning
In addition to his medical practice, Dr. Arun shared his commitment to education. “People are time-poor,” he noted. “That’s why I’ve been working on an audiobook to provide accessible information for those looking to better understand their health.”
Dr. Arun has authored several books and resources that focus on weight management, gut health, and building resilience:
Key Takeaways
GLP-1 medications offer promising results in weight loss and metabolic health but should be paired with lifestyle adjustments for optimal outcomes.
The gut microbiome significantly influences overall health and must be nurtured through diet and lifestyle changes.
Mindful eating and reducing environmental toxins are crucial for long-term well-being.
Strength training helps prevent muscle loss during weight loss efforts.
Accessible educational resources, like audiobooks and podcasts, empower individuals to make informed health choices.
Final Thoughts
The conversation between Jacqui Lewis and Dr. Arun Dhir highlights the importance of combining scientific advancements with practical lifestyle changes. As new treatments like GLP-1 medications gain traction, understanding their long-term effects—particularly on the microbiome—will be essential for sustainable health improvements.
For more expert insights, tune in to the latest episode of the Australian Weight Loss Surgery Podcast featuring Dr. Arun Dhir.
Connect with Dr. Arun Dhir
Website: www.DrArunDhir.com | www.BodyGenesis.com.au | www.MelbourneGastroSurgery.com.au
Facebook: www.facebook.com/youradicalwellness
Instagram: @dr_arun_dhir
YouTube: www.youtube.com/@drarundhir159